PGE2 displays immunosuppressive effects during human active tuberculosis

Abstract Prostaglandin E2 (PGE2), an active lipid compound derived from arachidonic acid, regulates different stages of the immune response host during several pathologies such as chronic infections or cancer. In fact, manipulation PGE2 levels was proposed approach for countering Type I IFN signature tuberculosis (TB). However, very limited information regarding pathway in patients with TB is currently available. present work, we demonstrated that exerts a potent immunosuppressive action human against Mycobacterium (Mtb) infection. Actually, showed significantly reduced surface expression immunological receptors, lymphoproliferation and production proinflammatory cytokines. addition, promoted autophagy monocytes neutrophils cultured Mtb antigens. These results suggest might be attenuating excessive inflammatory caused by , emerging attractive therapeutic target. Taken together, our findings contribute to knowledge role resistance highlight potential this mediator tool improve anti-TB treatment.